Panacur Liquid 10% 100ml

Presentation

A white oral suspension.

Composition

Fenbendazole: 10.000

Sodium methyl hydroxybenzoate: 0.200

Sodium propyl hydroxybenzoate: 0.020

Benzyl alcohol: 0.4835

Target species

Domestic dogs, cats, puppies and kittens.

Indications for use

A broad spectrum anthelmintic for the treatment of domestic dogs and cats infected with immature and mature stages of nematodes of the gastro-intestinal and respiratory tracts.

Adult dogs and cats: For the treatment of adult dogs and cats infected with gastro-intestinal nematodes and cestodes:

Ascarid spp. (Toxocara canis, Toxocara cati , Toxascaris leonina)

Ancylostoma spp.

Trichuris spp.

Uncinaria spp.

Taenia spp.

Puppies and kittens: For the treatment of puppies and kittens infected with gastro-intestinal nematodes and puppies infected with protozoa (Giardia spp.).

Pregnant dogs: For the treatment of pregnant dogs to reduce prenatal infections with Toxocara canis and the transfer of T.canis and Ancylostoma caninum to their pups via the milk.

Also for the treatment of domestic dogs infected with lungworm Oslerus (Filaroides) osleri or protozoa Giardia spp., and cats infected with lungworm Aelurostrongylus abstrusus.

Also has an ovicidal effect on nematode eggs.

Contra-indications

None known.

Special warnings for each target species

None.

Special precautions for use

(i) Special precautions for use in animals

Assess body weight as accurately as possible before calculating the dosage.

(ii) Operator warnings:

Direct contact with the skin should be kept to a minimum.

Wear impermeable rubber gloves and wash hands after use.

(iii) Other:

The use of this product should be based on local epidemiological information about susceptibility of the nematodes and recommendations on how to limit further selection for resistance to anthelmintics.  

Adverse reactions

Gastrointestinal signs (such as vomiting and diarrhoea) can occur in very rare cases in the dogs and cats.

The frequency of adverse reaction is defined using the following convention:

- very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)

- common (more than 1 but less than 10 animals in 100 animals)

- uncommon (more than 1 but less than 10 animals in 1,000 animals)

- rare (more than 1 but less than 10 animals in 10,000 animals)

- very rare (less than 1 animal in 10,000 animals, including isolated reports).

Use during pregnancy, lactation or lay

The product can be used in pregnant bitches. As teratogenic effects in dogs and cats cannot be completely ruled out in very rare cases, the treatment in the first two trimesters of pregnancy should be based on the benefit-risk evaluation by the responsible veterinary surgeon.

Interactions

None known.

Amounts to be administered and administration route

Shake the container before use.

Routine treatment of adult cats and dogs

1 ml per 1 kg body weight as a single oral dose (= 100 mg fenbendazole/kg body weight).

Practical dosage recommendations:

2 to 4 kg - 4 ml

4 to 8 kg - 8 ml

8 to 16 kg - 16 ml

16 to 24 kg - 24 ml

24 to 32 kg - 32 ml

32 to 64 kg - 64 ml

For dogs weighing over 64 kg, an extra 1 ml is required for each additional 1 kg body weight.

The dose should be mixed with feed, or administered orally directly after feeding.

Treatment should be repeated when natural reinfestation with parasitic worms occurs. Routine treatment of adult animals with minimal exposure to infection is advisable 2 to 4 times per year. More frequent treatment at 6 to 8 weekly intervals is advisable for dogs in kennels.

Puppies and kittens under six months of age

0.5 ml per kg body weight daily for 3 consecutive days given by mouth after feeding to unweaned animals or mixed with food for weaned animals (= 50 mg fenbendazole/kg body weight daily for 3 days).

Practical dosage recommendations:

Up to 1 kg - 0.5 ml daily for 3 days

1 to 2 kg - 1 ml daily for 3 days

2 to 4 kg - 2 ml daily for 3 days

4 to 6 kg - 3 ml daily for 3 days

6 to 8 kg - 4 ml daily for 3 days

8 to 10 kg - 5 ml daily for 3 days

For puppies weighing over 10 kg, an extra 0.5 ml is required daily for each additional kg body weight.

Puppies should be treated at 2 weeks of age, 5 weeks of age and again before leaving the breeders' premises.

Treatment may also be required at 8 and 12 weeks of age. Thereafter, frequency of treatment can be reduced unless the pups remain in kennels where reinfestation occurs more readily.

Pregnant dogs

1 ml per 4 kg body weight daily from day 40 of pregnancy continuously to 2 days post-whelping (approximately 25 days) (= 25 mg fenbendazole/kg body weight daily).

Practical dosage recommendations:

4 kg - 1 ml daily for approx. 25 days

8 kg - 2 ml daily for approx. 25 days

12 kg - 3 ml daily for approx. 25 days

20 kg - 5 ml daily for approx. 25 days

40 kg - 10 ml daily for approx. 25 days

For dogs weighing over 40 kg, an extra 1 ml is required daily for each additional 4 kg body weight.

As treatment of pregnant dogs is 98% effective, puppies from these dogs should themselves be treated with a three day course at 2 and 5 weeks of age.

Pregnant cats

Pregnant cats can be safely treated with this product but only require a single treatment at the routine adult dose rate. Administer 1 ml per 1 kg body weight as a single dose (=100 mg fenbendazole/kg body weight).

Increased dosing for specific infections

For the treatment of clinical worm infestations in adult dogs and cats or Giardia spp. infections in dogs administer 1 ml per 2 kg body weight daily for 3 consecutive days (= 50 mg fenbendazole/kg body weight daily for 3 days).

For the control of lungworm Oslerus (Filaroides) osleri in dogs administer 1 ml per 2 kg bod yweight daily for 7 consecutive days (= 50 mg fenbendazole/kg body weight daily for 7 days).

A repeat course of treatment may be required in some cases.

For the control of lungworm Aelurostrongylus abstrusus in cats administer 1 ml per 2 kg body weight daily for 3 consecutive days (= 50 mg fenbendazole/kg body weight daily for 3 days).

Overdose

Benzimidazoles have a high margin of safety. No specific overdose symptoms are known. No specific actions required.

Withdrawal periods

Not applicable.

Pharmacodynamic properties

ATC Vet Code: QP52AC13

Fenbendazole is an anthelmintic belonging to the benzimidazole carbamates group. It acts by interfering in the energy metabolism of the nematode. The anthelmintic efficacy is based on inhibition of the polymerisation of tubulin to microtubuli. The anthelmintic affects both adult and immature stages of gastro-intestinal and respiratory nematodes.

Pharmacokinetic properties

Fenbendazole is only partly absorbed after oral administration and is then metabolised in the liver. Fenbendazole and its metabolites are distributed throughout the body and high concentrations can be found in the liver. The elimination of fenbendazole and its metabolites occurs primarily via the faeces (>90%) and to a small extent in the urine and milk.

Fenbendazole is metabolised to its sulphoxide, then to sulphone and amines.

Legal Category

NFA-VPS 

You can see a directory of all veterinary medicines here

We acquired this data from the Noah Compendium, please see a link to this product here

If you have any queries please contact one of our Animal Medicines Advisors here